Nicotinamide mononucleotide (NMN) is a precursor to nicotinamide adenine dinucleotide (NAD+).
NAD+ is a compound found in every cell in your body and involved in many critical processes, including energy metabolism, DNA repair, and gene expression (22, 23).
NAD+ levels decline with age, and this decline is thought to be associated with accelerated physical decline and the onset of age-related diseases like Alzheimer’s (23).
Animal studies have shown that supplementing with NAD+ precursors NMN and NR restores NAD+ levels and prevents age-related physical decline.
For example, a study in aging mice demonstrated that supplementing orally with NMN prevented age-associated genetic changes and improved energy metabolism, physical activity, and insulin sensitivity (24).
Additionally, a 2019 study in 12 men with an average age of 75 showed that supplementing with 1 gram of NR daily for 21 days increased NAD+ levels in skeletal muscle and reduced levels of inflammatory proteins in the body (25).
Fisetin is a flavonoid compound that’s considered a senotherapeutic, meaning it can kill senescent cells.
Fisetin as an anticancer agent targeting the growth signaling pathways (F01).
Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential (F03).
Quercetin: A functional dietary flavonoid with potential chemo-preventive properties in colorectal cancer (Q3).
A preliminary investigation demonstrating the effect of quercetin on the expression of genes related to cell-cycle arrest, apoptosis and xenobiotic metabolism in human CO115 colon-adenocarcinoma cells using DNA microarray (Q4).
Quercetin, caffeic acid and Resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells (Q4).
Resveratrol is a polyphenol in grapes, berries, peanuts, and red wine that may promote longevity by activating certain genes called sirtuins. It has been shown to increase the lifespan of fruit flies, yeasts, and nematodes (42).
Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging (R4)
Resveratrol, an Nrf2 activator, alleviates aging-related progressive renal injury (R3)
Role of resveratrol in regulation of cellular defense systems against oxidative stress (R2).
Effect of resveratrol and pterostilbene on aging and longevity (R1).
Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a periodontitis model (R5).
Quercetin, caffeic acid and Resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells (Q4).
Astragalus membranaceus is a stress-reducing herb used in traditional Chinese medicine. It may help combat aging by reducing oxidative stress, promoting immune function, and preventing cellular damage (40).
Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro (A2).
Astragalus membranaceus: A Review of its Protection Against Inflammation and Gastrointestinal Cancers (A1).
Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives with astragalus (A3).
Experimental and clinical studies of mechanisms of the anti-aging effects of chemical compounds in Astragalus membranaceus (A4).
Astragalus (a traditional Chinese medicine) for treating chronic kidney disease (A5).
Curcumin — the main active compound in turmeric — has been shown to possess powerful anti-aging properties, which are attributed to its potent antioxidant potential.
Cellular senescence occurs when cells stop dividing. As you age, senescent cells accumulate, which is believed to accelerate aging and disease progression (2, 3).
Research demonstrates that curcumin activates certain proteins, including sirtuins and AMP-activated protein kinase (AMPK), which helps delay cellular senescence and promotes longevity (4, 5).
Plus, curcumin has been shown to combat cellular damage and significantly increase the lifespan of fruit flies, roundworms, and mice. This compound has been shown to postpone age-related disease and alleviate age-related symptoms as well (6, 7).
This may be why turmeric intake has been associated with a reduced risk of age-related mental decline in humans (8).
Epigallocatechin Gallate (EGCG)
Epigallocatechin gallate (EGCG) is a well-known polyphenol compound concentrated in green tea. It offers impressive health benefits, with research supporting its use to reduce the risk of certain cancers, as well as other health conditions like heart disease (9, 10, 11).
Among EGCG’s diverse array of potential health-promoting properties is its ability to promote longevity and protect against age-related disease development.
EGCG may slow aging by restoring mitochondrial function in cells and acting on pathways involved in aging, including the AMP-activated protein kinase signaling pathway (AMPK).
It also induces autophagy, the process by which your body removes damaged cellular material (12).
EGCG intake has been associated with a reduced risk of all-cause mortality, diabetes, stroke, and heart-disease-related death. Plus, animal studies have shown that it can protect against skin aging and wrinkles caused by ultraviolet (UV) light (13, 14, 15).
Collagen is promoted as a fountain of youth for its potential to reduce the appearance of skin aging.
It’s an integral component of your skin that helps maintain skin structure. As you age, collagen production slows, leading to collagen loss in the skin that accelerates signs of aging like wrinkles.
Some research suggests that supplementing with collagen may reduce signs of aging, including wrinkles and dry skin.
For example, a 2019 study in 72 women demonstrated that taking a supplement that contained 2.5 grams of collagen — along with several other ingredients, including biotin — per day for 12 weeks significantly improved skin hydration, roughness, and elasticity (16).
Another study in 114 women found that treatment with 2.5 grams of collagen peptides for 8 weeks significantly reduced eye wrinkles and increased collagen levels in the skin (17).
L-theanine is an amino acid concentrated in certain teas, including green tea. It may help protect against mental decline and has been shown to extend the lifespan of roundworms by around 5% (35, 36).
l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation (T1).
Protective Effect and Mechanism of Theanine on Lipopolysaccharide-Induced Inflammation and Acute Liver Injury (T2).
L-Theanine extends lifespan of adult Caenorhabditis elegans (T3).
The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent (T4).
l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry (T5).
Coenzyme Q10 (CoQ10) is an antioxidant that your body produces. It plays essential roles in energy production and protects against cellular damage (18).
Research suggests that levels of CoQ10 decline as you age, and supplementing with it has been shown to improve certain aspects of health in older individuals.
For example, a study in 443 older adults demonstrated that supplementing with CoQ10 and selenium over 4 years improved their overall quality of life, reduced hospital visits, and slowed the deterioration of physical and mental performance (19).
CoQ10 supplements help reduce oxidative stress, a condition characterized by an accumulation of free radicals and other reactive molecules that accelerates the aging process and onset of age-related disease (20, 21).
CoQ10 as A Promising Anti-aging Agent for Neurological Dysfunction in Brain Mitochondria (Q1).
Ubiquinone (coenzyme q10) and mitochondria in oxidative stress of parkinson's disease (Q2).
Crocin is a yellow carotenoid pigment in saffron, a popular, pricey spice that’s commonly used in Indian and Spanish cuisine.
Human and animal studies have shown that crocin offers many health benefits, including anticancer, anti-inflammatory, anti-anxiety, and antidiabetic effects (28).
Aside from the properties listed above, crocin has been researched for its potential to act as an anti-aging compound and protect against age-related mental decline (29).
Test-tube and rodent studies have demonstrated that crocin helps prevent age-related nerve damage by inhibiting the production of advanced glycation end products (AGEs) and reactive oxygen species (ROS), which are compounds that contribute to the aging process (30, 31).
Crocin has also been shown to help prevent aging in human skin cells by reducing inflammation and protecting against UV-light-induced cellular damage (32, 33).
Given that saffron is the most expensive spice in the world, a more cost-effective way to boost your crocin intake is by taking a concentrated saffron supplement.
Love it!!! It was exactly what I was looking for!
I can't say how it works, because I was about 3 weeks without the supplement, due it toke 1 month before I had my second one.
The company and their product has been top notch! My shipping was delayed and they got right on it and sent another bottle for free (expedited). Awesome product and customer service. I finally found a product that has everything in one bottle than having to take two different supplements in the morning and at night. I feel great! Thank you for this amazing product!
Excellent product. Feel with more energy. My nails lines due to my age(69y/o) went out after some months of use. Much less dry skin.My wife arthralgias resolved. Excellent customer service when there is a shipping dealy.I'm an Internal Medicine physician and it is my first review after some months of use waiting to see positive results. I hope more health benefits after continuing using.
WOW!!! I have only been taking this product for 2 months. I am a type 2 diabetic for the last 18 years. 4 years ago, I developed peripheral artery disease (PAD). Electrical pain, numbness, cold and hot feet, I had it all. 2021 I began Sanexas treatments that worked and reduced my pain from 10+ down to a 4. I was also receiving a vitamin cocktail injected into my feet 2x a week. It worked but after one year I had to stop treatment due to the cost. This year my level of pain was stable, and then I added your product to my diet. After using this product I noticed no more burning sensations in my feet. No cold sensations in my feet and less stinging sensations. Something good is happening. I wake up everyday feeling more sensations in my feet. My balance continues to improve. I will continue using this.
I take Aeon daily in conjunction with intermittent fasting and exercise (walking). I feel great and my significant weight loss has been sustained. So far so good!
First, I read the book Lifespan by David Sinclair PhD. Then I went on a search to find the most complete supplement on the market for anti-aging based on his research (and many other labs around the world). I'm very happy to say that I found AEON and it's the MOST COMPLETE product on the market! I have been taking it for a few months now and I feel amazing!!!
Good product. It gives me more energy.
Feeling better, improved general health conditions and looking forward to starting rejuvenating.
My wife and myself are aged in our mid 60’s have used AEON from Perpetua.Life for several months.
Previous to this we have consumed Tru Niagen for a couple of years and whilst this was helpful it was a narrow focussed supplement.
The AEON has NMN, plus a much more broad supplement content which we have found much more helpful. Hence we purchased a 6-month bulk supply because we definitely notice the improved health compared with only taking Niagen.
MY open water swim on July 17th 22. 3.3 km in 73 mins at 13 degrees celsius. Currently swimming 12 to 14 km a week even though it is winter here in Auckland NZ with other swimmers.
I like the broad coverage of this supplement eg Astralagus for immune support and Fisetin which is like having Strawberries out of season. I have never had Covid but have had 4 vaccinations. I am 66 yrs old in October 22.
Two months (bottles) into the supplement intervention including AEON and have to admit, I’m feeling great. 57 years old and recent blood biomarkers show me down 4.9 years from test done 3 months ago! Working for me for sure ….
I am using your products for 2 months.
It contain what we need for longevity in one bottle which is good
Delivery are on time and customer service is working very well
I feel more energized, vivid and focused
I think the mix of ingredients is very good.
Would like to see an additional product with some ingredients that are very promising with anti aging effects like anthocyanosises, spermidine, berberine and others that can be discussed so to have great complementary effects.
I seem to have more energy. I am 66 years old and still working a full time job. I also workout 3 times a week. One workout session is strength training and the other 2 is with a personal trainer and is more fitness with some light weights. I believe I am able to continue with this regime largely due to Aeon.
I know I feel younger, my skin is peeling all blemishes from my face, arms & neck. My holistic doctor says he thinks 120 years old is very possible. I mentioned the DNA projection and after these past 4 months, I may have reached the goal. Pain from my broken back(in 3 places) is almost totally gone(off all meds). Hope I do not look too young because I am hoping for a new companion my age to enjoy life with and pray he likes to dance or watch me. THANK YOU DOES NOT EXPRESS HOW I FEEL ABOUT 'PERPETUA.LIFE & WHAT IT HAS DONE FOR MY LIFE.
Compliments keep coming...and disbelief when friends say I look 50 & tell them my real age. My twin sister is asked if she is my older sister. We were always identical until now.
This has helped me keep my arthritic pain to a more tolerable level.
I feel I have tried most everything that is natural and I don't believe anything has helped like NMN supplements or NAD+ injections.
I recently had mesh removed from a hernia repair and I believe this might be the very best thing I have done for my pain since finding this supplement.
Please consider removing implants if you have arthritic pain after a surgery.
It's only been a month...that might be too early to to notice much
Great product! Feeling youthful and fresh everyday since I started it.
It's really wroth and working,energy level increased, no more inflammation and a better radiant complexion.
The products were delivered on time
Still not a great response but I feel it's working... It might take a bit more to full manifest the benefits. I will keep going and see. Thanks, P
Been using it for a month and will have my blood biomarkers tested again in 5 weeks. Feeling better but tough to tell until the bloodwork is done again.
Aeon is an ideal product for those who want to prolong their life and of course to improve their health! I will also recommend this product to my patients!
My skin looks improved , some wrinkles and spots have faded.
I love this supplement! To have so many benefitial ingredients in one supplement is amazing and saves money and space as well which I really appreciate. I like not having to open 10 separate bottles or more to take my daily supp regime. I would purchase it more often if I could. Thank-you for a quality product and quality service as well :)
Having NMN and Resveratrol and quercitin all in two pills is great!
What an amazing product packed full of ingredients and herbs which help your cell damage and oxidative and inflammatory stress placed on the bodies cells as well as giving you more energy to perform many tasks along with my health n fitness regime which is very important to me also giving your skin a youthful look the list goes on what it can do for you a great product in my armour thankyou.
A friend suggested that i include this formula in my health plan. My overall sense of well being has increased. Whatever deficits there could have been in my diet this supplement is a positive contribution to my nutrition.
Love having just one pill for all those good things!!
Gutes Mittel. Es ist jedoch noch zu früh und ich komme gerne darauf zurück. Dankeschön
so far is good experience
Erfahrung zu kurz...
A ouina B.
The product is good. Delivery timely.
It's great to find most of the anti-aging supplements that I seek in the one capsule. Before I would run out of one supplement or another and it might be months before I reordered. With AEON subscription I'm getting consistency without having to actively stay on top of things. I love it!
It gave me back my energy and I am starting to look younger I would recommend this to anyone lacking energy
I have now taken AEON for a month. I was hesitant to write a review earlier because I was concerned that the increased energy that I felt was a "placebo effect". I am no longer in doubt! I am enjoying a general feeling of well being and definitely an increase in my energy. I am 88, joined a gym and have doubled the time and effort involved in my exercise. I plan on being a customer of PerpetuaLife for the rest of my life. Also, their customer service has been outstanding!
Emilio I.V. G.
I'm going younger and younger.
This product contains many herbs that are very effective in positively supporting aging delay by interfering with important aging pathways
Andrea Danielle C.
Excellent product, it has given me back my health better and more energy every day, I recommend it...Really thank you so much!
It’s effective and I am finding that it works well with my gym protocols. There is an up-tic is memory. I need on one tablet in the a.m. The suggested amount might work for others, as for me one tablet is fine.
Jose Alberto U.
It’s amazing how fast it works
Great product! Just what I was looking for! Thank you.
WOW. Is all I can say at 82 and recovering from a broken back injury. Now with so much energy and beginning to dance again. Thank you for making my life happy again. I notice my skin has began to feel smoothe, dark spots are disappearing and my energy has returned. The most important thing is I no longer need meds for pain because my pain is almost totally gone.
The delivery was very quick to my home which I appreciate. I seen to have more physical strength
since taking it for only a few days.
Well done job in every way.
I has been taking the supplements for three months. So far feel really good. I has noticed a brighter skin, and an overall improvement in my stamina.
I have found this product extremely supportive for myself and along with good old walking & heavy weights it’s a home run! Buy it people it’s the real stuff.
I noticed a considerable difference in energy. I reviewed several products and really feel this one is the best. Going to subscribe for monthly delivery
I was taking several of the active ingredients separately from other manufacturers and it was very expensive. This formulation (Aeon) has most all of the currently recognized life enhancing/extending substances in one dose per day (two capsules) for a very reasonable price. I have lost 30 lbs of body fat in the last 6 months using these molecules. I’ve lost 5 of the 30 lbs after switching to the Aeon formulation a little over a month ago. So I am very pleased with the Aeon formulation so far
All going good ...heaps of energy at the gym, obviously it's hard to know what's going on inside in these relatively early days of longevity supplements but no apparent side effects and feeling good
46 this year
Chronological age 29
Great stuff ! I will continue to take them in future if you let me very happy
Very good products
It seems to give me more energy but I'm looking at long term use after doing the research so all good.
My skin tone has improved and changed my look to a more radient glow.
The spots on my hands are getting lighter my hands seem much smoother. Perpetua-Life gave me the hope I needed & the energy to live to 120 years old as doctor predicted. The pain from a back injury is almost gone. Adding your product to my daily routine is the only change. Thank you for this product, and looking forward to see how I look in 2 or 3 months. The men on my dating site ask for woman over forty & I clearly state my age(82). I truly believe your product is life saving & the "Fountain of Youth". Bless everyone that has contributed to this product. Please keep supplies in stock because I want to be assured of it's continued availability. Your loyal customer,
Carol McFadden Weakley, CEO, WOSB
I've just started, but feeling better more energy. Will review in 6 months.
HELPS A LOT IT'S GAME CHANGER, WORKS FAST LIKE DR'S PRESCRIPTION DRUG EXCEPT IS NTURL & NO CHEMICALS, IT'S GOD'S CREATION, FIRST MONTH I FILL MY SKIN LOOKS YOUNG & HEALTHY < I WILL CONTINUE ANTHILL I LOOK LIKE 50 YEARS OLD, I'M 68 Yrs , NO MORE , BACK TO MY YOUNG AGES, GOOD JOB GUYS I WILL CONTINUE TAKING , MABY SOON I STOP AGING , & GET YOUNGER & YOUNGER, WOOW FROM CKB007
Hello there ! Maybe its a little to early to say but I am confident sure that its just cos I watch a podcast whith Andrew huberman and he recommended it . So I want to be by it every month
In my forty some odd years of experimenting with anti-aging supplements, never had I had such an immediate and discernible change in energy and mood as I have had with AEON. I was quite taken back and immediately wanted to confirm AEON is what it says it is. Perpetua LIfe staff were very helpful in directing me to the proper independent resources to confirm the supplement was indeed what it claims. I was in excellent health when I started taking AEON two months ago so the increase in energy was very surprising but even more so was the change in my mental attitude. I just felt more relaxed and happier. Can I explain it, no. Do I think AEON is the cause...let me just say that I have been around the aging supplement game for quite some time and I would know if these results for me were the result of a placebo effect. Therefore, I recommend AEON wholeheartedly and without reservation. RR
Im using it as a go to strategy for longevity. Seems to be stabalising some of the longstanding issues that have come and go in my body - bone aches and bone density loss, mood swings, energy levels. I do take other supplements to manage bone density, neural functions and moods, but this one seems to enhance the effectiveness of all the others. Its gives me a stable baseline to adjust from.
So far don’t feel any side effects nor stomach upset.
I find it to give more energy & make me alert: feeling good
Fantastic product, absolutely amazing quality and it works!
I take 2 capsules in the morning with a tall glass of water (this flushes your stomach after sleep) on a empty stomach, cannot recommend highly enough. You will notice a difference after a few days. I’m a subscriber in OZ and the service is brilliant I’ve emailed this company and they have been quick and extremely helpful in their service , so a great product and a great business to deal with, I’m a very happy customer.
OMG! Obviously based on anecdotal evidence but I’ve been balding for years and now after 3 months on AEON new sharp little hairs are growing everywhere on my scalp (I don’t even use Rogain). As you can imagine I’m absolutely thrilled, I just hope these results aren’t temporary!
I follow Prof.David Sinclair (fellow Aussie) and his work so a natural progression was to find some of the ingredients for healthspan improvement that his lab promotes. After finding and taking Aeon I found an increase in energy more than anything. Due to a delivery problem I've been without it for 6 days and have noticed a drop off in energy in the gym, as to what other benefits come from your product, time will tell. Cheers
Early days but working well. Im 75 an very healthy so I am looking to be super healthy
I feel the beneficial effect of this supplement! Recommended!
Great anti- aging product. Easily tolerated.
Love the fact that this product has all the supplements I normally take separately in one single dose. Not only is it cheaper but it’s also more convenient this way. I’m making the switch. Great customer support that resolved my issue immediately and went over and above. This company is serious about earning your business.
Can’t go wrong with AEON! My entire focus has become living a healthier life, so I can keep enjoying life longer. AEON is by far the best & most affordable product on the market. A 500mg NMN dose alone cost more everywhere I’ve looked.
Just got my first bottle in the mail. Very excited to try this.
AEON is great, I’m very familiar with all the components that are in it. I’ve been taking many for years but switched to AEON because it’s a cheaper and more comprehensive solution. I split my dose by taking one capsule in the AM and the other in the PM.
I've been taking AEON for about 2 months now & I absolutely feel more energized, and optimistic about life. My work performance has increased and my skin looks much younger. I kid you not people keep asking me if I'm wearing makeup (and II'm a guy).
I was looking for an affordable Fisetin/Quercetin supplement. This one is amazing plus the added bonus of NMN! Will stay on it long term.
Motivation and mood improvements.
I am finishing my second month and have noticed improvements in my hair and nails. Motivation and mood have also seen positive change.
Just started taking AEON as it seems to be a relatively new product. I'll report back in a month but so fa i'm happy with it; truly nothing on the market like it.
This is a World Class product that has benefitted my health significantly since I started taking it. I'm very involved in Longevity research & the SENS foundation, and was very surprised t actually took a company this long to put together a product like this.
i suppose they'd rather you buy a dozen supplements individually then make one that has everything.
This is one supplement , I know I can't miss. Can’t say that about any other one. I’ve even recommended AEON to family and friends, and the only supplement that I’ve recommended.
Was previously taking 4 of the supplements that are already in AEON so I'm saving money now & getting more for it!
AEON™ is independently tested for authenticity and contaminants. It's manufactured in an FDA-registered facility according to GMP guidelines in Norcross, Georgia and distributed by Perpetua.Life in Casper, Wyoming.
❖ Although some of the compounds found in AEON™ may be used to treat or prevent certain ailments, AEON™ as a product is considered a dietary supplement, and as such has not been FDA approved to treat or prevent any diseases. You should speak to your doctor before taking AEON™ to make sure it's safe for you to do so. The statements made about AEON™ are based on research studies conducted on its ingredients, and have not been evaluated by the Food and Drug Administration. To date no clinical trials have been conducted utilizing AEON™ itself.
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