Nicotinamide mononucleotide (NMN) is a precursor to nicotinamide adenine dinucleotide (NAD+).
NAD+ is a compound found in every cell in your body and involved in many critical processes, including energy metabolism, DNA repair, and gene expression (22, 23).
NAD+ levels decline with age, and this decline is thought to be associated with accelerated physical decline and the onset of age-related diseases like Alzheimer’s (23).
Animal studies have shown that supplementing with NAD+ precursors NMN and NR restores NAD+ levels and prevents age-related physical decline.
For example, a study in aging mice demonstrated that supplementing orally with NMN prevented age-associated genetic changes and improved energy metabolism, physical activity, and insulin sensitivity (24).
Additionally, a 2019 study in 12 men with an average age of 75 showed that supplementing with 1 gram of Nicotinamide daily for 21 days increased NAD+ levels in skeletal muscle and reduced levels of inflammatory proteins in the body (25).
Fisetin is a flavonoid compound that’s considered a senotherapeutic, meaning it can kill senescent cells.
Fisetin as an anticancer agent targeting the growth signaling pathways (F01).
Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential (F03).
Quercetin: A functional dietary flavonoid with potential chemo-preventive properties in colorectal cancer (Q3).
A preliminary investigation demonstrating the effect of quercetin on the expression of genes related to cell-cycle arrest, apoptosis and xenobiotic metabolism in human CO115 colon-adenocarcinoma cells using DNA microarray (Q4).
Quercetin, caffeic acid and Resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells (Q4).
Resveratrol is a polyphenol in grapes, berries, peanuts, and red wine that may promote longevity by activating certain genes called sirtuins. It has been shown to increase the lifespan of fruit flies, yeasts, and nematodes (42).
Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging (R4)
Resveratrol, an Nrf2 activator, alleviates aging-related progressive renal injury (R3)
Role of resveratrol in regulation of cellular defense systems against oxidative stress (R2).
Effect of resveratrol and pterostilbene on aging and longevity (R1).
Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a periodontitis model (R5).
Quercetin, caffeic acid and Resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells (Q4).
Astragalus membranaceus is a stress-reducing herb used in traditional Chinese medicine. It may help combat aging by reducing oxidative stress, promoting immune function, and preventing cellular damage (40).
Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro (A2).
Astragalus membranaceus: A Review of its Protection Against Inflammation and Gastrointestinal Cancers (A1).
Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives with astragalus (A3).
Experimental and clinical studies of mechanisms of the anti-aging effects of chemical compounds in Astragalus membranaceus (A4).
Astragalus (a traditional Chinese medicine) for treating chronic kidney disease (A5).
Curcumin — the main active compound in turmeric — has been shown to possess powerful anti-aging properties, which are attributed to its potent antioxidant potential.
Cellular senescence occurs when cells stop dividing. As you age, senescent cells accumulate, which is believed to accelerate aging and disease progression (2, 3).
Research demonstrates that curcumin activates certain proteins, including sirtuins and AMP-activated protein kinase (AMPK), which helps delay cellular senescence and promotes longevity (4, 5).
Plus, curcumin has been shown to combat cellular damage and significantly increase the lifespan of fruit flies, roundworms, and mice. This compound has been shown to postpone age-related disease and alleviate age-related symptoms as well (6, 7).
This may be why turmeric intake has been associated with a reduced risk of age-related mental decline in humans (8).
Epigallocatechin Gallate (EGCG)
Epigallocatechin gallate (EGCG) is a well-known polyphenol compound concentrated in green tea. It offers impressive health benefits, with research supporting its use to reduce the risk of certain cancers, as well as other health conditions like heart disease (9, 10, 11).
Among EGCG’s diverse array of potential health-promoting properties is its ability to promote longevity and protect against age-related disease development.
EGCG may slow aging by restoring mitochondrial function in cells and acting on pathways involved in aging, including the AMP-activated protein kinase signaling pathway (AMPK).
It also induces autophagy, the process by which your body removes damaged cellular material (12).
EGCG intake has been associated with a reduced risk of all-cause mortality, diabetes, stroke, and heart-disease-related death. Plus, animal studies have shown that it can protect against skin aging and wrinkles caused by ultraviolet (UV) light (13, 14, 15).
Collagen is promoted as a fountain of youth for its potential to reduce the appearance of skin aging.
It’s an integral component of your skin that helps maintain skin structure. As you age, collagen production slows, leading to collagen loss in the skin that accelerates signs of aging like wrinkles.
Some research suggests that supplementing with collagen may reduce signs of aging, including wrinkles and dry skin.
For example, a 2019 study in 72 women demonstrated that taking a supplement that contained 2.5 grams of collagen — along with several other ingredients, including biotin — per day for 12 weeks significantly improved skin hydration, roughness, and elasticity (16).
Another study in 114 women found that treatment with 2.5 grams of collagen peptides for 8 weeks significantly reduced eye wrinkles and increased collagen levels in the skin (17).
L-theanine is an amino acid concentrated in certain teas, including green tea. It may help protect against mental decline and has been shown to extend the lifespan of roundworms by around 5% (35, 36).
l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation (T1).
Protective Effect and Mechanism of Theanine on Lipopolysaccharide-Induced Inflammation and Acute Liver Injury (T2).
L-Theanine extends lifespan of adult Caenorhabditis elegans (T3).
The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent (T4).
l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry (T5).
Coenzyme Q10 (CoQ10) is an antioxidant that your body produces. It plays essential roles in energy production and protects against cellular damage (18).
Research suggests that levels of CoQ10 decline as you age, and supplementing with it has been shown to improve certain aspects of health in older individuals.
For example, a study in 443 older adults demonstrated that supplementing with CoQ10 and selenium over 4 years improved their overall quality of life, reduced hospital visits, and slowed the deterioration of physical and mental performance (19).
CoQ10 supplements help reduce oxidative stress, a condition characterized by an accumulation of free radicals and other reactive molecules that accelerates the aging process and onset of age-related disease (20, 21).
CoQ10 as A Promising Anti-aging Agent for Neurological Dysfunction in Brain Mitochondria (Q1).
Ubiquinone (coenzyme q10) and mitochondria in oxidative stress of parkinson's disease (Q2).
Crocin is a yellow carotenoid pigment in saffron, a popular, pricey spice that’s commonly used in Indian and Spanish cuisine.
Human and animal studies have shown that crocin offers many health benefits, including anticancer, anti-inflammatory, anti-anxiety, and antidiabetic effects (28).
Aside from the properties listed above, crocin has been researched for its potential to act as an anti-aging compound and protect against age-related mental decline (29).
Test-tube and rodent studies have demonstrated that crocin helps prevent age-related nerve damage by inhibiting the production of advanced glycation end products (AGEs) and reactive oxygen species (ROS), which are compounds that contribute to the aging process (30, 31).
Crocin has also been shown to help prevent aging in human skin cells by reducing inflammation and protecting against UV-light-induced cellular damage (32, 33).
Given that saffron is the most expensive spice in the world, a more cost-effective way to boost your crocin intake is by taking a concentrated saffron supplement.
Within a few days of taking AEON longevity complex both my husband and I noticed that we had more energy, slept better and overall feeling of encouragement. My husband is type 2 diabetic and is blood sugar levels became easier to manage without increasing medication. Additionally our body composition started changing with clear muscle definition as energy and strength increased during our workouts. With so many supplements on the market promising to improve health / life span it's truly a relief to find a company that produces such quality products that deliver on their promise. The customer care is outstanding responding to emails promptly with answers to questions and providing sound guidance. Well done !
I heard, it can kill cancer cells and I hope it will do this work very well.
Like this product, 2 pills every day, I feel great
Yielded an increase of a nice quiet deeper Energy; like the motor just has some more torque deep inside. Also in the brain, really small but I know myself very well. My weakness is tiredness. I keep it in check with breathing and functional food - but this really made a I would say impactful difference! After 2 days I would like to add.
Super počutje. Veliko energije.
I'm 73. Aeon seems to improve my Balance and my Mood. Overall it seems to help me feel Centered.
Just what I ordered, thanx
Excellent combination, etc.
Additional Magnesium , say 200mg per capsule, would counter effect of Calcium buildup in arteriosclerosis.
AEON is an excellent anti-aging.
I can see the results in my body.
Excellent product and service.Will purchase again.
A mi esposa y a mi , nos parece un producto fabulozo, tenemos menos de 1 mes de usarlo y ya observamos mejaoras en la piel , en el rostro , y esperamos que en poco tiempo podamos expirimentar los beneficios de sus componentes , hemos pensado recomendarlo a otros familiares y espramos que se animen a probarlo .....
good service amazing ingredients only second bottle do not feel any better yet but based on ingredients I surely believe I will
I just started to use the product. So far so good. More info later...
Thankyou so much!!...just love the product and feeling better than ever...will continue forever...happy customer!...Take care...Don Pope in Canada.
Its first time I getting it
its okay but results still not
It does seem to make me stronger and healthier. I have swum 7km 3 times this year and have swum up to 3hrs 20 mins in open water sea conditions and carry on with my day.
I swam 4 km this morning in the sea with strong Nor East winds and then carry onto work.
Fill and look 10 years younger, I broke a record in swimming more 10% faster…then before.
I feel a difference. I'm more fresh. I like to take it and will keep taking it.
Peter H. Switzerland
I'm taking Aeon for the compounds it contains as the foundation for my Longevity treatment. I take other supplements too.
Have used it for 2 month s not as effective as the beginning. But still makes. A difference. Will continue to to use
I'm 78 and female. Feel great with lots of energy. I bought a years supply and love the fact that it includes the things I was buying separately which means I have saved a lot of money. Will know better when I've been on the product longer as I am just on my second bottle.
More energy, my skin looking younger, among other improvements. It really works.
A wonderful product. The whole family drinks it. I started drinking the first pack. I feel very well. There is only one problem with me out of the whole family. It makes me very nervous. So I have reduced it and drink one a day and I feel perfect.
The support team was very responsive
They helped me with the delivery for Romania.
The product feels great so far, much more energized
I was initially quite skeptical of this supplement, and chose it as a convenient way to try out a few of the compounds in it without having a huge up-front investment in something that was a dud for me. One month in, and it has blown me away. I'm a fairly average woman in her mid 40s and I'm taking two pills a day. It took a week or so for me to notice the difference, but from that point on the effects have been unreal and they seem to be getting more noticeable (I'm sure they'll plateau, but no sign of that yet). Since starting these pills, I feel like I'm 25 years younger than I am. I have amazing energy, my mood is more elevated, concentration improved and my libido is off the charts. More promising - my cardio endurance has much improved (previously 45 min spin with low to moderate resistance was about my max, now I can do a 90 min ride at a faster cadence and increased resistance with no problem - some of that is because I've been really working on it, but the jump from 45 and wiped to 90 and feeling pleasantly flushed happened in the space of a week, so I'm crediting this supplement for a good part of this improvement), and I can see some muscle definition in my legs and arms. It was like this product hit some sort of reboot switch, and I love it. The one issue I've had is with the shipping to Canada. It's like maple syrup in January, and seems inefficient (UPS to USPS to Canada Post) - esp for the price and the tracking is stunningly vague. I'm slightly worried that the second bottle won't arrive before I'm finished with the first bottle so I may have to get a spare bottle so I don't have to deal with running out while I wait 10 - 14 days for delivery.
It is very professional from You to ask me about my experience with AEON.
After taking it I feel more energy in my everyday activities (I am 81 old). So I have serious thinking about subscribing it.
With best wishes in Your scientific activities in Anti- Aging supplements field.
I believe in it!
Great product. Very unique in the types and amounts of ingredients. Feeling wonderful after having been on it for 2 weeks now. Would highly recommend it.
Jong Yong L.
My purchase this month already paid and confirmed has not been delivered yet???
Please kindly verify whereabout the product you said was sent to me???
I do not know any of your delivery tracking code, etc.
Thanks for your clarification swiftly.
Jong Yong Lee
Fühle mich gesünder und jünger
The manager has handled my order timely as I live in Europe. Less than a month, I am so satisfied with the product that I ordered for another whole year. Many thanks!
This a good products and it is delivered on time
Iy is very convenient to have all ingredients ot once
Been on it for a few weeks now and I've got to say I love it!
I feel good. I feel like I have more energy and as if my immune system is holding up better than it normally does.
Usually, I am the first to get sick in my household, but this time around, several of my family members have gotten sick and I'm still not showing any symptoms 1 week in.
You could say that this might of course be coincidence and has nothing to do with me getting sick or no, but fact is; I'm still feeling overall better than I have in a long time.
Note; I am doing a lot of other things besides taking these pills to help me stay in good health and hopefully live a long life.
But it seems to me these are helping in keeping my energy levels stabilized and hopefully helping maximize longevity.
If Dr. David Sinclair is to be believed they do contain many of the ingredients proven to promote longevity. (Check him and his studies out!)
Love long a prosper folks!
Note; The pills took a while to get to me here in Norway, so brace yourself with a little bit of patience if your living situation is anything like mine in the ways of delivery distance.
I wish I had found this medicine earlier. It contains all the supplements I am aware of and several more.
This is early days and I'm already feeling great.
It has most of the components that I am looking for. Some I take an additional amount to bring up the level to what I see recommended i.e. Fisetin. Overall a great product and makes it easy when traveling so that I do not have to take so many different pills.
I had read a lot about anti-ageing supplements and on paper this product looked like a all in one solution. I have been very satisfied with the product, my energy levels are drastically up and I feel great! I would recommend this product to anyone. Also customer service has been the best, they have always stepped in when there were shipping issues. well done!
A very complete and effective supplement.
Feeling better everyday, recommend hughly
Emilio I. V. G.
There on the roof you see me painting my house built around the
big norwegian inmigration to the USA, around that time Abraham Lincoln was baby. I am 73 years old there.
Good product please make it in a liquid form so I can injected straight in to the blood stream
Hi, well I seem to have more energy and feel pretty good. This could be a placebo effect I guess?? I don't know, what do you think I should feel or expect? In any case I need you to send me 2 boxes in the next shipment then stop shipments as I will be in the United States for the winter and will be on the move from time to time in our RV until April 15, 2023 when I return to Edmonton. Can't have pills sitting in an outdoor community mailbox all winter when you get 20/30c below temperatures. This will be a continuous problem year after year. Look forward to your reply. Thanks Lorne.
52 years of age, makes me feel 40 after 2- months of taking this awesome supplement! Monthly subscription 100%
I believe in it ……
Only two weeks has passed and so far so good Let's seen if the product is helping me for the better.
I feel alert & energise
I am extremely pleased, for the following reasons:
1. Ordering from the website is simple, intuitive, and scaleable to individual needs
2. Customer service response, when needed, is prompt and effective
3. I have only recently started using this product, on my 3rd bottle now. There seems to be a faintly discernable feeling of being more energetic, and a better sleep pattern.
The experience is very subjective and perhaps too soon to actually vouch for the product's efficacy, and I will be most happy to share my experience againat a later date, after more prolonged usage.
Good price but resveratrol and NMN daily is half what I need so I will have to double the dose (which I'll try after a month if no side effects - not sure of the effect of the increased does of fisetin et al).
I have been taking it for about 6 months. I added some additional NMN and Fisetin to the amount in the formula to get it to the numbers recommended by David Sinclair and others. I will continue to purchase the product.
I’ve only been using a few weeks and I feel like I have more energy, improved memory and can handle a hangover a lot better ;) It’s a very good start and the results so far are enough to make me want to give it a few months trial before I subscribe. So I just bought another bottle. It’s pricey but the ingredient combo is impressive and would cost so much more if I bought separately.
Great customer service, I live in Mauritius so the shipping is often a challenge. The team at perpetua is always very reactive and helps a lot
Improving general health, from what I can tell. Thanks. Laurence J
Great product! All our family loves it. Fast delivery, will be ordering again.
Energy from day one. Brain fog gone love this product I’m so much more productive. Puts me in a great mood. Helps with my chronic neck pain. Will reorder
Love it!!! It was exactly what I was looking for!
I can't say how it works, because I was about 3 weeks without the supplement, due it toke 1 month before I had my second one.
The company and their product has been top notch! My shipping was delayed and they got right on it and sent another bottle for free (expedited). Awesome product and customer service. I finally found a product that has everything in one bottle than having to take two different supplements in the morning and at night. I feel great! Thank you for this amazing product!
Excellent product. Feel with more energy. My nails lines due to my age(69y/o) went out after some months of use. Much less dry skin.My wife arthralgias resolved. Excellent customer service when there is a shipping dealy.I'm an Internal Medicine physician and it is my first review after some months of use waiting to see positive results. I hope more health benefits after continuing using.
WOW!!! I have only been taking this product for 2 months. I am a type 2 diabetic for the last 18 years. 4 years ago, I developed peripheral artery disease (PAD). Electrical pain, numbness, cold and hot feet, I had it all. 2021 I began Sanexas treatments that worked and reduced my pain from 10+ down to a 4. I was also receiving a vitamin cocktail injected into my feet 2x a week. It worked but after one year I had to stop treatment due to the cost. This year my level of pain was stable, and then I added your product to my diet. After using this product I noticed no more burning sensations in my feet. No cold sensations in my feet and less stinging sensations. Something good is happening. I wake up everyday feeling more sensations in my feet. My balance continues to improve. I will continue using this.
I take Aeon daily in conjunction with intermittent fasting and exercise (walking). I feel great and my significant weight loss has been sustained. So far so good!
First, I read the book Lifespan by David Sinclair PhD. Then I went on a search to find the most complete supplement on the market for anti-aging based on his research (and many other labs around the world). I'm very happy to say that I found AEON and it's the MOST COMPLETE product on the market! I have been taking it for a few months now and I feel amazing!!!
Good product. It gives me more energy.
Feeling better, improved general health conditions and looking forward to starting rejuvenating.
My wife and myself are aged in our mid 60’s have used AEON from Perpetua.Life for several months.
Previous to this we have consumed Tru Niagen for a couple of years and whilst this was helpful it was a narrow focussed supplement.
The AEON has NMN, plus a much more broad supplement content which we have found much more helpful. Hence we purchased a 6-month bulk supply because we definitely notice the improved health compared with only taking Niagen.
MY open water swim on July 17th 22. 3.3 km in 73 mins at 13 degrees celsius. Currently swimming 12 to 14 km a week even though it is winter here in Auckland NZ with other swimmers.
I like the broad coverage of this supplement eg Astralagus for immune support and Fisetin which is like having Strawberries out of season. I have never had Covid but have had 4 vaccinations. I am 66 yrs old in October 22.
Two months (bottles) into the supplement intervention including AEON and have to admit, I’m feeling great. 57 years old and recent blood biomarkers show me down 4.9 years from test done 3 months ago! Working for me for sure ….
I am using your products for 2 months.
It contain what we need for longevity in one bottle which is good
Delivery are on time and customer service is working very well
I feel more energized, vivid and focused
I think the mix of ingredients is very good.
Would like to see an additional product with some ingredients that are very promising with anti aging effects like anthocyanosises, spermidine, berberine and others that can be discussed so to have great complementary effects.
I seem to have more energy. I am 66 years old and still working a full time job. I also workout 3 times a week. One workout session is strength training and the other 2 is with a personal trainer and is more fitness with some light weights. I believe I am able to continue with this regime largely due to Aeon.
I know I feel younger, my skin is peeling all blemishes from my face, arms & neck. My holistic doctor says he thinks 120 years old is very possible. I mentioned the DNA projection and after these past 4 months, I may have reached the goal. Pain from my broken back(in 3 places) is almost totally gone(off all meds). Hope I do not look too young because I am hoping for a new companion my age to enjoy life with and pray he likes to dance or watch me. THANK YOU DOES NOT EXPRESS HOW I FEEL ABOUT 'PERPETUA.LIFE & WHAT IT HAS DONE FOR MY LIFE.
Compliments keep coming...and disbelief when friends say I look 50 & tell them my real age. My twin sister is asked if she is my older sister. We were always identical until now.
This has helped me keep my arthritic pain to a more tolerable level.
I feel I have tried most everything that is natural and I don't believe anything has helped like NMN supplements or NAD+ injections.
I recently had mesh removed from a hernia repair and I believe this might be the very best thing I have done for my pain since finding this supplement.
Please consider removing implants if you have arthritic pain after a surgery.
It's only been a month...that might be too early to to notice much
Great product! Feeling youthful and fresh everyday since I started it.
It's really wroth and working,energy level increased, no more inflammation and a better radiant complexion.
The products were delivered on time
Still not a great response but I feel it's working... It might take a bit more to full manifest the benefits. I will keep going and see. Thanks, P
Been using it for a month and will have my blood biomarkers tested again in 5 weeks. Feeling better but tough to tell until the bloodwork is done again.
Aeon is an ideal product for those who want to prolong their life and of course to improve their health! I will also recommend this product to my patients!
My skin looks improved , some wrinkles and spots have faded.
I love this supplement! To have so many benefitial ingredients in one supplement is amazing and saves money and space as well which I really appreciate. I like not having to open 10 separate bottles or more to take my daily supp regime. I would purchase it more often if I could. Thank-you for a quality product and quality service as well :)
Having NMN and Resveratrol and quercitin all in two pills is great!
What an amazing product packed full of ingredients and herbs which help your cell damage and oxidative and inflammatory stress placed on the bodies cells as well as giving you more energy to perform many tasks along with my health n fitness regime which is very important to me also giving your skin a youthful look the list goes on what it can do for you a great product in my armour thankyou.
A friend suggested that i include this formula in my health plan. My overall sense of well being has increased. Whatever deficits there could have been in my diet this supplement is a positive contribution to my nutrition.
Love having just one pill for all those good things!!
Gutes Mittel. Es ist jedoch noch zu früh und ich komme gerne darauf zurück. Dankeschön
so far is good experience
Erfahrung zu kurz...
A ouina B.
The product is good. Delivery timely.
It's great to find most of the anti-aging supplements that I seek in the one capsule. Before I would run out of one supplement or another and it might be months before I reordered. With AEON subscription I'm getting consistency without having to actively stay on top of things. I love it!
It gave me back my energy and I am starting to look younger I would recommend this to anyone lacking energy
AEON™ is independently tested for authenticity and contaminants. It's manufactured in an FDA-registered facility according to GMP guidelines in Norcross, Georgia and distributed by Perpetua.Life in Casper, Wyoming.
❖ Although some of the compounds found in AEON™ may be used to treat or prevent certain ailments, AEON™ as a product is considered a dietary supplement, and as such has not been FDA approved to treat or prevent any diseases. You should speak to your doctor before taking AEON™ to make sure it's safe for you to do so. The statements made about AEON™ are based on research studies conducted on its ingredients, and have not been evaluated by the Food and Drug Administration. To date no clinical trials have been conducted utilizing AEON™ itself.